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Tirzepatide targets two hormonal pathways (GLP-1 and GIP), while Semaglutide targets one

Instead, it is a complex behavior influenced by multiple factors, including central reward processing, food hedonic value, gut-originated reward pathways, gut microbiota environment, genetics, cognition, and psychological factors, such as anxiety and depression [35]

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Best results come when paired with a calorie-appropriate diet, activity, sleep, and hydration